Tuesday, March 4, 2008

Hypertrophic Cardiomyopathy continued...inbreeding linkage established...


From gene mutation to clinical disease A. Gene mutations cause clinical disease. Two important questions remain the focus of research now and in the future; what is the signalling pathway leading from a gene defect to the clinical phenotype, and secondly, how is this process modified by either genetic and/or environmental factors, e.g. exercise, diet. B. Role of gene modifiers in mice with HCM. Left ventricular wall thickness (LVWT) measurements in 3 groups of mice; wildtype (wt), inbred mice (SvEv) with the Arg403Gln mutation and outbred mice (BSwiss) with the Arg403Gln mutation. An LVWT assessed by echocardiography greater than 1.0 mm (dashed horizontal line) indicates hypertrophy. Approximately 50% of mutant mice in the BSwiss genetic background are protected from developing hypertrophy.

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1 comment:

grovecanada said...

Hello Lisa,

I read your misquote of what I wrote here...Funny how you didn't even bother to look at the graph or research that I posted...It is so characteristic that you have without reading properly
posted a hysterical accusation...How typical...Why did you think I posted ON MY OWN BLOG ...Your slander is terribly unintellectual...Too bad you didn't spend more time thinking & less time in this crazy weird bout of judgmentalism that seems to have destroyed so much good online...Please do not return here or further slander me...I am not inviting the kind of evil maliciousness that ruined the pedigree site...GO AWAY...